ea0049ep20 | Adrenal cortex (to include Cushing's) | ECE2017
Catalano Rosa
, Peverelli Erika
, Giardino Elena
, Treppiedi Donatella
, Morelli Valentina
, Chiodini Iacopo
, Marcon Lorenzo
, Ronchi Cristina L
, Bertherat Jerome
, Beuschlein Felix
, Arosio Maura
, Spada Anna
, Mantovani. Giovanna
The cAMP signaling pathway plays a major role in the pathogenesis of cortisol-producing adrenocortical adenomas (CPA). In adrenocortical cells cAMP induces dramatic changes in cell morphology accompanied by actin cytoskeleton rearrangements that precede steroidogenesis, the causal relationship between these events being still undefined. In this study we investigated cAMP effects on cytoskeleton rearrangements and steroidogenic response in mouse (Y1) and human adrenocortical tu...